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Drug-Induced Nutrient Depletions
Prescription Drug Category
Nutrients Depleted
Female hormones
Estrogen replacement therapy Vitamin B6, magnesium
Oral contraceptives Vitamins B1, B2, B3, B6, B12, C, folic acid, magnesium, selenium, zinc, tyrosine
Blood pressure regulators
Hydralazine Vitamin B6, Coenzyme Q10
Loop diuretics Calcium, magnesium, potassium, sodium, zinc, vitamins B1, B6, vitamin C
Thiazide diuretics Magnesium, phosphorus, potassium, sodium, zinc, Coenzyme Q10
Potassium-sparing diuretics Folic acid, calcium, zinc
Blood pressure regulators Zinc
Cholesterol-lowering drugs
Hydromymethylglutaryl Coenzyme Q10, coenzyme A reductase inhibitors (statins)
Bile acid sequestrants Vitamins A, D, E, K, B12, beta-carotene, folic acid, calcium, iron, magnesium
Gemfibrozil phosphorus, zinc, fat ("fibrates" deplete vitamin E, Vitamin B12, copper, zinc), Coenzyme Q10, vitamin E
Anticonvulsants
Phenobarbital and barbiturates Vitamin D and K, biotin, folic acid, calcium
Phenytoin Vitamin D, Vitamin K, folic acid, vitamins B1 and B12, biotin, calcium
Carbamazepine Vitamin D, folic acid, biotin
Primidone Biotin, folic acid, vitamins D and K
Valproic acid Folic acid, carnitine
Anti-inflammatory drugs
Corticosteroids Vitamins A, C, D, B12, folic acid, calcium, chromium, magnesium, potassium selenium, zinc
Gout medications Beta-carotene, vitamin B12, calcium, sodium, potassium, phosphorus
Sulfasalazine Folic acid
Indomethacin Folic acid, iron
Other nonsteroidal anti-inflammatory drugs Folic acid
Antibiotics
Antibiotics (General) Acidophilus and Bifidus, all B vitamins, vitamin K
Tetracycline antibiotics Calcium, magnesium, iron
Tuberculosis drugs Vitamin B3, vitamin B6, vitamin D
Neomycin Beta-carotene, calcium, magnesium, iron, potassium, vitamin A, vitamin B12
Trimethoprim Biotin, folic acid, inositol, B vitamins, vitamin K
Anti-diabetic drugs
Sulfonylureas Coenzyme Q10, vitamin E
Biguanides Coenzyme Q10, vitamin B12, folic acid
Ulcer medications
H2-receptor antagonists Vitamin B12, folic acid, vitamin D, calcium, iron, zinc (protein)*
Proton pump inhibitors Vitamin B12 (protein)*
Other categories and/or commonly prescribed drugs
Digoxin Calcium, magnesium, phosphorus
Beta blockers Coenzyme Q10, melatonin
Tricyclic antidepressants Coenzyme Q10, vitamin B2
Phenothiazines Coenzyme Q10, vitamin B2, melatonin
Potassium chloride supplementation Vitamin B12
Chemotherapeutic drugs Most nutrients
Theophylline Vitamin B6
Anticoagulants Vitamin K
Reverse transcriptase inhibitors Copper, zinc, vitamin B12, carnitine
Over-the-counter drugs
Aspirin Vitamin C, folic acid, iron, potassium
NSAIDs Folic acid
Laxatives-mineral oil Vitamins A, D, E, K, beta carotene
Laxatives-bisacodyl Potassium
Magnesium and aluminum antacids Calcium, phosphate, folic acid, (protein)*
Sodium bicarbonate Folic acid, magnesium, potassium, (protein)*
Ulcer medications Vitamin B12, folic acid, vitamin D, zinc
*Problems with the digestion of proteins with use of these drugs have not been documented by scientific studies. However, it is well known that stomach acid is required for proper protein digestion. Therefore, drugs that either neutralize stomach acid or suppress the production of stomach acid are likely to have a
negative effect on protein digestion. The passing of undigested protein from the stomach into the small intestine may also cause health problems in its own right.

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